This patient was a 50-year-old male with a prostatic mitral valve who was receiving long-term antibiotics for endocarditis. Died of acute cardiac failure. At autopsy, a large vegetation/thrombus completely obstructed the prosthetic mitral valve mechanism. Additional key findings are pictured. Your job is to deduce the chain of events that led to the findings pictured below.
Above: H&E from mitral vegetation
Above: Gross of thyroid lobe and cute surface
Above: H&E photomicrograph of thyroid gland, high power